Article
Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias.
Circulation - 20 Dec 2011
Morrow John P, Katchman Alexander, Son Ni-Huiping, Trent Chad M, Khan Raffay, Shiomi Takayuki, Huang Haiyan, Amin Vaibhav, Lader Joshua M, Vasquez Carolina, Morley Gregory E, D'Armiento Jeanine, Homma Shunichi, Goldberg Ira J, Marx Steven O
Abstract excerpt
BACKGROUND: Diabetes mellitus and obesity, which confer an increased risk of sudden cardiac death, are associated with cardiomyocyte lipid accumulation and altered cardiac electric properties, manifested by prolongation of the QRS duration and QT interval. It is difficult to distinguish the contribution of cardiomyocyte lipid accumulation from the contribution of global metabolic defects to the increased...
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