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Article

Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jun 2006

Arany Zoltan, Novikov Mikhail, Chin Sherry, Ma Yanhong, Rosenzweig Anthony, Spiegelman Bruce M

Abstract excerpt

Heart failure is accompanied by important defects in metabolism. The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) is a powerful regulator of mitochondrial biology and metabolism. PGC-1alpha and numerous genes regulated by PGC-1alpha are repressed in models of cardiac stress, such as that generated by transverse aortic constriction (TAC). This finding...

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Source

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Identifiers

PMID: 16775082
DOI: 10.1073/pnas.0603615103
PMCID: PMC1502510

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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