Article
Systemic lupus erythematosus patients under immunosuppressive treatment express high levels of the immunoglobulin lambda variable IGLV8S1 gene with silent somatic mutations.
Biochimica et biophysica acta - 2 Jan 2002
Tamia-Ferreira Marcia Cristina, Trevisan Glauce L, de Carvalho Ivan Fiore, Passos Geraldo A S
Abstract excerpt
Systemic lupus erythematosus (SLE) patients express high titers of somatically mutated serum autoantibodies against nuclear structures including double-stranded DNA. These somatic mutations accumulate codons for basic amino acids in the immunoglobulin variable regions of both, heavy and light chains, facilitating binding to nucleic acids. The variable (V) immunoglobulin lambda 8 (IGLV8S1) gene contributes to...
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