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Neutralizing anti-DNase1L3 antibodies derive from autoreactive VH4-34<sup>+</sup>-B cells and associate with the interferon signature in SLE

2021-06-09

Abstract excerpt

DNase1L3 deficiency is an inborn error of immunity that causes monogenic systemic lupus erythematosus (SLE) in humans. Here, we identified that one third of patients with sporadic SLE have antibodies to DNase1L3. Like DNase1L3 deficiency, we found that patients with anti-DNase1L3 antibodies have features associated with immune pathways activated by immunogenic self-DNA, including elevated antibodies to dsDNA and p...

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Identifiers and source

Literature Corpus work
523f9e97-ac11-5eb2-bdba-c71ad9fdd2cf
DOI
10.1101/2021.06.07.21258180
Open publication

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Neutralizing anti-DNase1L3 antibodies derive from autoreactive VH4-34<sup>+</sup>-B cells and associate with the interferon signature in SLEDOI 10.1101/2021.06.07.21258180
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