Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcript mutations of the alpha regulatory subunit of protein kinase A and up-regulation of the RNA-editing gene transcript in lupus T lymphocytes.

Lancet (London, England) - 14 Sept 2002

Laxminarayana Dama, Khan Islam U, Kammer Gary

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterised by diverse dysfunctions of immune effector cells, including proliferation and cytotoxicity. In T cells from patients with SLE, activity of type 1 protein kinase A isozymes is greatly reduced because of decreased expression of the alpha and beta regulatory subunits (RI alpha and RI beta). We aimed to identify a molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Deaminase
Share to Cyclic AMP-Dependent Protein Kinase RIalpha Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

Share to Lupus Erythematosus, Systemic

Share to Ribonucleoproteins

Share to RNA-Binding Proteins

Share to RNA Editing

Share to RNA-Induced Silencing Complex

Source

Identifiers

PMID: 12243919
DOI: 10.1016/s0140-6736(02)09966-x

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcript mutations of the alpha regulatory subunit of protein kinase A and up-regulation of the RNA-editing gene transcript in lupus T lymphocytes.PMID 12243919Read ↗

mRNA mutations of type I protein kinase A regulatory subunit alpha in T lymphocytes of a subject with systemic lupus erythematosus.Semantic proximity Read ↗

Altered editing in cyclic nucleotide phosphodiesterase 8A1 gene transcripts of systemic lupus erythematosus T lymphocytes.Semantic proximity Read ↗

Altered editing in RNA editing adenosine deaminase ADAR2 gene transcripts of systemic lupus erythematosus T lymphocytes.Semantic proximity Read ↗

Induction of 150-kDa adenosine deaminase that acts on RNA (ADAR)-1 gene expression in normal T lymphocytes by anti-CD3-epsilon and anti-CD28.Semantic proximity Read ↗

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature.Semantic proximity Read ↗

Single nucleotide polymorphisms in the gene encoding the major histocompatibility complex class II transactivator (CIITA) in systemic lupus erythematosus.Semantic proximity Read ↗

Human RNA-specific adenosine deaminase <i>ADAR1</i> transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducibleSemantic proximity Read ↗

Polymorphisms/mutations of TCR-zeta-chain promoter and 3' untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3' untranslated region in patients with systemic lupus erythematosus.Semantic proximity Read ↗

A regulatory SNP at position -899 in CDKN1A is associated with systemic lupus erythematosus and lupus nephritis.Semantic proximity Read ↗

Defective Expression of Ras Guanyl Nucleotide-Releasing Protein 1 in a Subset of Patients with Systemic Lupus ErythematosusSemantic proximity Read ↗

Decreased DAP12 expression in natural killer lymphocytes from patients with systemic lupus erythematosus is associated with increased transcript mutations.Semantic proximity Read ↗

Mutations in T cell receptor zeta chain mRNA of peripheral T cells from systemic lupus erythematosus patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.