Article
Structure of the VH and VL segments of monoreactive and polyreactive IgA autoantibodies to DNA in patients with systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1994
Kasaian M T, Ikematsu H, Balow J E, Casali P
Abstract excerpt
Anti-DNA IgA autoantibodies play an important immunopathologic role in SLE patients. To analyze the cellular origin and the VH and VL structure of anti-DNA IgA autoantibodies, we generated five IgA1 mAbs to DNA using B lymphocytes from three SLE patients. Two mAbs bound to ssDNA only and one to b...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Antibodies, Antinuclear
- Antibodies, Monoclonal
- Base Sequence
- DNA
- Female
- Humans
- Immunoglobulin A
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Lupus Erythematosus, Systemic
- Middle Aged
- Molecular Sequence Data
- Mutation