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Article

[Mutation of human mismatch repair genes in hereditary nonpolyposis colorectal cancer (HNPCC) families].

Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Mar 1999

Yuan Y, Huang J, Zheng S

Abstract excerpt

OBJECTIVE: To investigate germline mutations of mismatch repair genes hMLH1 and hMSH2 in 29 HNPCC families. METHODS: Mutations were detected by PCR-SSCP analysis, and confirmed by DNA sequencing. RESULTS: (1) In 29 families, the overall mutation rate of these two genes was 31.0% (9/29). Mutation detected in all of the 9 families was located in the hMLH1 gene, indicating that the hMLH1 gene was the main...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11776847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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