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Article

Mismatch Repair and the Hereditary Non-polyposis Colorectal Cancer Syndrome (HNPCC)

1 Jan 2002

Abstract excerpt

The hereditary non-polyposis colorectal cancer (HNPCC)-syndrome is the most common form of hereditary colorectal cancers, and accounts for 2-7% of the total colorectal cancer burden. Since there are no single clinical features specific for HNPCC, diagnosis is based on family history (Amsterdam or Bethesda criteria) and is confirmed by the detection of a mutation in one of the responsible mismatch repair (MMR)...

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PMID: 11852992
DOI: 10.1081/cnv-120000371

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Source receipt: pubmed, retrieved 7 Sept 2026.

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