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Article

hMSH2 is the most commonly mutated MMR gene in a cohort of Greek HNPCC patients.

British journal of cancer - 31 Jan 2005

Apessos A, Mihalatos M, Danielidis I, Kallimanis G, Agnantis N J, Triantafillidis J K, Fountzilas G, Kosmidis P A, Razis E, Georgoulias V A, Nasioulas G

Abstract excerpt

Germline mutations in genes encoding proteins involved in DNA mismatch repair are responsible for the autosomal dominantly inherited cancer predisposition syndrome hereditary nonpolyposis colorectal cancer (HNPCC). We describe here analysis of hMLH1 and hMSH2 in nine Greek families referred to our centre for HNPCC. A unique disease-causing mutation has been identified in seven out of nine (78%) families. The...

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Identifiers

PMID: 15655560
DOI: 10.1038/sj.bjc.6602260
PMCID: PMC2361846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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