Article
[Clinical analysis and molecular genetic study of hereditary nonpolyposis colorectal cancer kindreds].
Zhonghua wai ke za zhi [Chinese journal of surgery] - 7 Feb 2004
Luo Ding-cun, Cai Qi, Sun Meng-hong, Ni Yao-zhong, Tao Chong-wei, Chen Zhe-jing, Shi Da-ren
Abstract excerpt
OBJECTIVE: To study the clinicopathological and molecular genetic characteristics of hereditary nonpolyposis colorectal cancer (HNPCC), to enable the early diagnosis and to evaluate the treatment. METHODS: We analyzed 12 families of HNPCC from Wenzhou, Zhejiang province, China. Mismatch repair genes hMSH2 and hMLH1 expression and microsatellite instability of tumor tissue were studied using microdissection,...
Topics
- Adaptor Proteins, Signal Transducing
- Adult
- Aged
- Carrier Proteins
- China
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Mutational Analysis
- DNA, Neoplasm
- DNA-Binding Proteins
- Family Health
- Female
- Humans
- Immunohistochemistry