Article
[Clinical analysis and molecular genetic study of hereditary nonpolyposis colorectal cancer kindreds].
Zhonghua wai ke za zhi [Chinese journal of surgery] - 7 Feb 2004
Luo Ding-cun, Cai Qi, Sun Meng-hong, Ni Yao-zhong, Tao Chong-wei, Chen Zhe-jing, Shi Da-ren
Abstract excerpt
OBJECTIVE: To study the clinicopathological and molecular genetic characteristics of hereditary nonpolyposis colorectal cancer (HNPCC), to enable the early diagnosis and to evaluate the treatment. METHODS: We analyzed 12 families of HNPCC from Wenzhou, Zhejiang province, China. Mismatch repair genes hMSH2 and hMLH1 expression and microsatellite instability of tumor tissue were studied using microdissection,...
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