Article
[Disruption of mismatch repair system in human cancers].
Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 1996
Fukushige S, Horii A
Abstract excerpt
It is known that transformation of normal cells to cancer cells is caused by the accumulation of successive mutations in oncogenes and/or tumor suppressor genes. Since four DNA mismatch repair genes (hMSH2, hMLH1, hPMS1 and hPMS2) have been identified as the cause of hereditary nonpolyposis color...
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