hMLH1 and hMSH2 gene mutation in Brazilian families with suspected hereditary nonpolyposis colorectal cancer.

doi:10.1007/BF02573891

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Article

hMLH1 and hMSH2 gene mutation in Brazilian families with suspected hereditary nonpolyposis colorectal cancer.

Annals of surgical oncology - 1 Jul 2002

Rossi Benedito Mauro, Lopes Ademar, Oliveira Ferreira Fabio, Nakagawa Wilson Toshihiko, Napoli Ferreira Cláudia C, Casali Da Rocha José C, Simpson Catarina C, Simpson Andrew J G

Abstract excerpt

BACKGROUND: The aim of this study was to search for mutations in the human mutS homolog 2 (hMSH2) and human mutL homolog 1 (hMLH1) genes in 25 unrelated Brazilian kindreds with suspected hereditary nonpolyposis colorectal cancer (HNPCC). METHODS: The families were grouped according to the following clinical criteria: Amsterdam I or II; familial colorectal cancer (CRC); an early age of onset of CRC in the proband...

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PMID: 12095971
DOI: 10.1007/BF02573891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.