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[Mutation of hMLH1 and hMSH2 genes in hereditary nonpolyposis colorectal cancer: analysis of 76 probands].

Zhonghua yi xue za zhi - 22 Jul 2008

Fu Lei, Sheng Jian-qiu, Sun Zi-qin, Han Min, Huang Ji-sheng, Mu Hong, Han Wen-liang, Niu Hong-li, Li Ai-qin, Wu Zi-tao, Li Shi-rong

Abstract excerpt

OBJECTIVE: To investigate the mutations of the mismatch repair genes hMLH1 and hMSH2 in hereditary nonpolyposis colorectal cancer (HNPCC). METHODS: The DNA samples of 76 probands of HNPCC families underwent PCR amplification and sequencing on 35 exons in hMLH1 and hMSH2 genes. RESULTS: (1) The overall mutation rate of the hMLH1 and hMSH2 genes was 33% (25/76). (2) 22 mutations were found, 16 in the hMLH1 gene and...

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PMID: 19062740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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