Mismatch repair gene mutation analysis and colonoscopy surveillance in Chinese Lynch syndrome families.

doi:10.1007/s13402-013-0130-z

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Mismatch repair gene mutation analysis and colonoscopy surveillance in Chinese Lynch syndrome families.

Cellular oncology (Dordrecht, Netherlands) - 1 Jun 2013

Fu Lei, Sheng Jian-qiu, Li Xiao-ou, Jin Peng, Mu Hong, Han Min, Huang Ji-sheng, Sun Zi-qin, Li Ai-qin, Wu Zi-tao, Li Shi-rong

Abstract excerpt

BACKGROUND: Lynch syndrome (or HNPCC) is a colorectal cancer syndrome caused by germline mutations in either one of the DNA mismatch repair (MMR) genes hMLH1, hMSH2, hMSH6 or hPMS2. Mutations in hMLH1 and hMSH2 are most prevalent. Here we aimed to determine the cancer risk of MMR gene mutation carriers and, in addition, the efficacy of colonoscopy surveillance in Chinese Lynch syndrome family members with and...

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PMID: 23640085
DOI: 10.1007/s13402-013-0130-z
PMCID: PMC13012685

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