Article
Identification of a critical site in Wld(s): essential for Nmnat enzyme activity and axon-protective function.
Neuroscience letters - 8 Feb 2007
Jia Haiqun, Yan Tingting, Feng Yan, Zeng Chengming, Shi Xianglin, Zhai Qiwei
Abstract excerpt
The chimeric Wld(s) protein consisting of the N-terminal 70 amino acids of Ufd2 and the complete sequence of nicotinamide mononucleotide adenylyltransferase1 (Nmnat1), delays Wallerian degeneration in Wld(s) mice. Although Nmnat1 enzyme activity was showed to be critical for the function of Wld(s) protein, the expected phenotype was not observed in Nmnat1 transgenic mice. To further check whether Nmnat1 enzyme...
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