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Article

A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivation.

The Journal of physiology - 1 Nov 2006

Xiong Wei, Farukhi Yousaf Z, Tian Yanli, Disilvestre Deborah, Li Ronald A, Tomaselli Gordon F

Abstract excerpt

The molecular mechanisms underlying slow inactivation in sodium channels are elusive. Our results suggest that EEDD, a highly conserved ring of charge in the external vestibule of mammalian voltage-gated sodium channels, undermines slow inactivation. By employing site-directed mutagenesis, we found that charge alterations in this asymmetric yet strong local electrostatic field of the EEDD ring significantly...

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Identifiers

PMID: 16873407
DOI: 10.1113/jphysiol.2006.115105
PMCID: PMC1890405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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