Article
Inactivation determinants in segment IIIS6 of Ca(v)3.1.
The Journal of physiology - 15 Nov 2001
Marksteiner R, Schurr P, Berjukow S, Margreiter E, Perez-Reyes E, Hering S
Abstract excerpt
1. Low threshold, T-type, Ca(2+) channels of the Ca(v)3 family display the fastest inactivation kinetics among all voltage-gated Ca(2+) channels. The molecular inactivation determinants of this channel family are largely unknown. Here we investigate whether segment IIIS6 plays a role in Ca(v)3.1 inactivation as observed previously in high voltage-activated Ca(2+) channels. 2. Amino acids that are identical in...
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