Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel molecular inactivation determinant of voltage-gated CaV1.2 L-type Ca2+ channel.

Neuroscience - 1 Jan 2006

Livneh A, Cohen R, Atlas D

Abstract excerpt

The inactivation of voltage-gated L-type Ca(2+) channels (Ca(V)1) regulates Ca(2+) entry and controls intracellular Ca(2+) levels that are essential for cellular activity. The molecular entities implicated in L-channel (Ca(V)1.2) inactivation are not fully identified. Here we show for the first time the functional impact of one of the two highly conserved clusters of six negatively charged glutamates and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Barium
Share to Calcium Channels, L-Type
Share to Dose-Response Relationship, Radiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electric Stimulation

Share to Ion Channel Gating

Share to Microinjections

Share to Molecular Conformation

Share to Xenopus

Source

Identifiers

PMID: 16533566
DOI: 10.1016/j.neuroscience.2006.01.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel molecular inactivation determinant of voltage-gated CaV1.2 L-type Ca2+ channel.PMID 16533566Read ↗

Molecular determinants of inactivation in voltage-gated Ca2+ channels.Semantic proximity Read ↗

Molecular determinants of voltage-dependent slow inactivation of the Ca2+ channel.Semantic proximity Read ↗

Identification of the components controlling inactivation of voltage-gated Ca2+ channels.Semantic proximity Read ↗

Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on L-type calcium channel gating.Semantic proximity Read ↗

Inactivation of L-type calcium channels is determined by the length of the N terminus of mutant beta(1) subunits.Semantic proximity Read ↗

Gating charge immobilization in Kv4.2 channels: the basis of closed-state inactivation.Semantic proximity Read ↗

Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions.Semantic proximity Read ↗

Inactivation determinants in segment IIIS6 of Ca(v)3.1.Semantic proximity Read ↗

Introduction into Ca(v)2.1 of the homologous mutation of Ca(v)1.2 causing the Timothy syndrome questions the role of V421 in the phenotypic definition of P-type Ca(2+) channel.Semantic proximity Read ↗

Characterization of specific allosteric effects of the Na+ channel β1 subunit on the Nav1.4 isoform.Semantic proximity Read ↗

Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation.Semantic proximity Read ↗

Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.