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Article

Involvement of local anesthetic binding sites on IVS6 of sodium channels in fast and slow inactivation.

Neuroscience letters - 30 Jan 2003

Bai Chang-Xi, Glaaser Ian W, Sawanobori Tohru, Sunami Akihiko

Abstract excerpt

Local anesthetics (LAs) block Na(+) channels with a higher affinity for the fast or slow inactivated state of the channel. Their binding to the channel may stabilize fast inactivation or induce slow inactivation. We examined the role of the LA binding sites on domain IV, S6 (IVS6) of Na(+) channels in fast and slow inactivation by studying the gating properties of the mutants on IVS6 affecting LA binding....

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Identifiers

PMID: 12524167
DOI: 10.1016/s0304-3940(02)01288-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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