Article
Involvement of CDC25Mm/Ras-GRF1-dependent signaling in the control of neuronal excitability.
Molecular and cellular neurosciences - 1 Dec 2001
Tonini R, Franceschetti S, Parolaro D, Sala M, Mancinelli E, Tininini S, Brusetti R, Sancini G, Brambilla R, Martegani E, Sturani E, Zippel R
Abstract excerpt
Ras-GRF1 is a neuron-specific guanine nucleotide exchange factor for Ras proteins. Mice lacking Ras-GRF1 (-/-) are severely impaired in amygdala-dependent long-term synaptic plasticity and show higher basal synaptic activity at both amygdala and hippocampal synapses (Brambilla et al., 1997). In the present study we investigated the effects of Ras-GRF1 deletion on hippocampal neuronal excitability....
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