Alterations in frequency coding and activity dependence of excitability in cultured neurons of Drosophila memory mutants.

Article

Alterations in frequency coding and activity dependence of excitability in cultured neurons of Drosophila memory mutants.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Mar 1997

Zhao M L, Wu C F

Abstract excerpt

Mutants of the Drosophila dunce (dnc) and rutabaga (rut) genes, which encode a cAMP-specific phosphodiesterase and a calcium/calmodulin-responsive adenylyl cyclase, respectively, are deficient in short-term memory. Altered synaptic plasticity has been demonstrated at neuromuscular junctions in th...

Topics

Action Potentials
Animals
Cells, Cultured
Drosophila
Female
Memory
Mutation
Neurons
Patch-Clamp Techniques

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