Article
Alterations in frequency coding and activity dependence of excitability in cultured neurons of Drosophila memory mutants.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Mar 1997
Zhao M L, Wu C F
Abstract excerpt
Mutants of the Drosophila dunce (dnc) and rutabaga (rut) genes, which encode a cAMP-specific phosphodiesterase and a calcium/calmodulin-responsive adenylyl cyclase, respectively, are deficient in short-term memory. Altered synaptic plasticity has been demonstrated at neuromuscular junctions in these mutants, but little is known about how their central neurons are affected. We examined this problem by using the...
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