Article
Possible involvement of Rap1 and Ras in glutamatergic synaptic transmission.
Neuroreport - 1 Jul 2003
Imamura Y, Matsumoto N, Kondo S, Kitayama H, Noda M
Abstract excerpt
Rap1A, first identified as a suppressor of transformed phenotype induced by an activated ras oncogene, is abundantly expressed in the brain. Its neurophysiological function, however, is poorly understood. When an activated Rap1A mutant (Rap1-12V) or a dominant negative H-Ras mutant (Ras-17N) was expressed in CA1 neurons in cultured hippocampal slices using the sindbis virus-mediated gene transfer technique, NMDA...
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