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Article

Regulation of cortical dendrite development by Rap1 signaling.

Molecular and cellular neurosciences - 1 Feb 2005

Chen Yachi, Wang Phyllis Y, Ghosh Anirvan

Abstract excerpt

Rap1 is a small GTP-binding protein that has been implicated in intracellular signaling and cytoskeletal control. Here, we show that Rap1 is expressed in rat cortical neurons and plays a critical role in dendritic development. Inhibition of Rap1 signaling either by expressing dominant negative mutant of Rap1 or Rap1GAP in cortical neurons reduced dendritic complexity. In contrast, expression of a constitutively...

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Identifiers

PMID: 15691704
DOI: 10.1016/j.mcn.2004.08.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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