Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.

doi:10.1016/s0896-6273(03)00404-5

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.

Neuron - 17 Jul 2003

Morozov Alexei, Muzzio Isabel A, Bourtchouladze Rusiko, Van-Strien Niels, Lapidus Kyle, Yin DeQi, Winder Danny G, Adams J Paige, Sweatt J David, Kandel Eric R

Abstract excerpt

Learning-induced synaptic plasticity commonly involves the interaction between cAMP and p42/44MAPK. To investigate the role of Rap1 as a potential signaling molecule coupling cAMP and p42/44MAPK, we expressed an interfering Rap1 mutant (iRap1) in the mouse forebrain. This expression selectively decreased basal phosphorylation of a membrane-associated pool of p42/44MAPK, impaired cAMP-dependent LTP in the...

Topics

Animals
Antirheumatic Agents
Bacterial Proteins
Behavior, Animal
Blotting, Western
Colforsin
Conditioning, Psychological
Cues
Cyclic AMP
Electric Stimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Electrophysiology

Excitatory Postsynaptic Potentials

Gene Expression Regulation, Enzymologic

Hippocampus

Immunoenzyme Techniques

In Situ Hybridization

Interleukin 1 Receptor Antagonist Protein

Long-Term Potentiation

Source

Open in PubMed

Identifiers

PMID: 12873387
DOI: 10.1016/s0896-6273(03)00404-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.PMID 12873387Read ↗

Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.Semantic proximity Read ↗

Partial inhibition of PP1 alters bidirectional synaptic plasticity in the hippocampus.Semantic proximity Read ↗

Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability.Semantic proximity Read ↗

NMDA receptor-dependent long-term potentiation in mouse hippocampal interneurons shows a unique dependence on Ca(2+)/calmodulin-dependent kinases.Semantic proximity Read ↗

Ras and Rap control AMPA receptor trafficking during synaptic plasticity.Semantic proximity Read ↗

Synaptic plasticity deficits in a mouse model of Timothy syndrome: LTP saturation and its pharmacological rescue by nifedipine.Semantic proximity Read ↗

Possible involvement of Rap1 and Ras in glutamatergic synaptic transmission.Semantic proximity Read ↗

The Pin1-CaMKII-AMPA Receptor Axis Regulates Epileptic Susceptibility.Semantic proximity Read ↗

Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory.Semantic proximity Read ↗

Mice lacking the adenosine A1 receptor have normal spatial learning and plasticity in the CA1 region of the hippocampus, but they habituate more slowly.Semantic proximity Read ↗

Cell type-specific roles of RAS-MAPK signaling in learning and memory: Implications in neurodevelopmental disordersSemantic proximity Read ↗

The alpha-Ca2+/calmodulin kinase II: a bidirectional modulator of presynaptic plasticity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.