Article
CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
Science (New York, N.Y.) - 3 Oct 2003
Marsicano Giovanni, Goodenough Sharon, Monory Krisztina, Hermann Heike, Eder Matthias, Cannich Astrid, Azad Shahnaz C, Cascio Maria Grazia, Gutiérrez Silvia Ortega, van der Stelt Mario, López-Rodriguez Maria Luz, Casanova Emilio, Schütz Günther, Zieglgänsberger Walter, Di Marzo Vincenzo, Behl Christian, Lutz Beat
Abstract excerpt
Abnormally high spiking activity can damage neurons. Signaling systems to protect neurons from the consequences of abnormal discharge activity have been postulated. We generated conditional mutant mice that lack expression of the cannabinoid receptor type 1 in principal forebrain neurons but not in adjacent inhibitory interneurons. In mutant mice,the excitotoxin kainic acid (KA) induced excessive seizures in...
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