Article
FGFs control the patterning of the inner ear but are not able to induce the full ear program.
Mechanisms of development - 1 Dec 2001
Adamska M, Herbrand H, Adamski M, Krüger M, Braun T, Bober E
Abstract excerpt
FGF2 or FGF8 applied ectopically, close to the developing otic placode enhances transcription of a subset of ear marker genes such as Nkx5-1, SOHo1 and Pax2. Other ear expressed genes (Dlx5 and BMP4) are not up-regulated by FGFs. Ectopic FGFs lead to an increase in size of the vestibulo-cochlear ganglion. This phenotypic change is due to an increased recruitment of epithelial cells to the neuronal fate rather...
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