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Article

Lmx1a is required for segregation of sensory epithelia and normal ear histogenesis and morphogenesis.

Cell and tissue research - 1 Dec 2008

Nichols David H, Pauley Sarah, Jahan Israt, Beisel Kirk W, Millen Kathleen J, Fritzsch Bernd

Abstract excerpt

At embryonic day 8.5, the LIM-homeodomain factor Lmx1a is expressed throughout the otic placode but becomes developmentally restricted to non-sensory epithelia of the ear (endolymphatic duct, ductus reuniens, cochlea lateral wall). We confirm here that the ears of newborn dreher (Lmx1a (dr)) mutants are dysmorphic. Hair cell markers such as Atoh1 and Myo7 reveal, for the first time, that newborn Lmx1a mutants...

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Identifiers

PMID: 18985389
DOI: 10.1007/s00441-008-0709-2
PMCID: PMC2654344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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