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Article

Characterization of new otic enhancers of the pou3f4 gene reveal distinct signaling pathway regulation and spatio-temporal patterns.

PloS one - 31 Dec 2010

Robert-Moreno Àlex, Naranjo Silvia, de la Calle-Mustienes Elisa, Gómez-Skarmeta José Luis, Alsina Berta

Abstract excerpt

POU3F4 is a member of the POU-homedomain transcription factor family with a prominent role in inner ear development. Mutations in the human POU3F4 coding unit leads to X-linked deafness type 3 (DFN3), characterized by conductive hearing loss and progressive sensorineural deafness. Microdeletions found 1 Mb 5' upstream of the coding region also displayed the same phenotype, suggesting that cis-regulatory elements...

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Identifiers

PMID: 21209840
DOI: 10.1371/journal.pone.0015907
PMCID: PMC3013142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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