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Article

Development of the lip and palate: FGF signalling.

Frontiers of oral biology - 1 Jan 2012

Stanier Philip, Pauws Erwin

Abstract excerpt

The fibroblast growth factor (FGF) signalling pathway is critically involved in several aspects of craniofacial development, including formation of the lip and the palate. FGF receptors are activated by extracellular FGF ligands in order to regulate cellular processes such as migration and morphogenesis through instruction of specific target gene expression. A key factor in the development of orofacial structures...

Topics

Cleft Lip
Cleft Palate
Embryonic Development
Fibroblast Growth Factors
Gene Expression Regulation, Developmental
Humans
Lip
Mutation
Palate
Receptors, Fibroblast Growth Factor
Signal Transduction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22759671
DOI: 10.1159/000337618

Genes

FGF8
FGFR1
FGFR2
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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