Article
Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 May 2005
Ohuchi Hideyo, Yasue Akihiro, Ono Katsuhiko, Sasaoka Shunsuke, Tomonari Sayuri, Takagi Akira, Itakura Mitsuo, Moriyama Keiji, Noji Sumihare, Nohno Tsutomu
Abstract excerpt
Fibroblast growth factor (FGF) signaling is crucial for the induction and growth of the ear, a sensory organ that involves intimate tissue interactions. Here, we report the abnormality of Fgf10 null ear and the identification of a cis-regulatory element directing otic expression of Fgf10. In Fgf10 null inner ears, we found that the initial development of semicircular, vestibular, and cochlear divisions is roughly...
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