Article
Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification.
Development (Cambridge, England) - 1 May 2003
Liu Dong, Chu Hsin, Maves Lisa, Yan Yi-Lin, Morcos Paul A, Postlethwait John H, Westerfield Monte
Abstract excerpt
The vertebrate inner ear develops from the otic placode, an ectodermal thickening that forms adjacent to the presumptive hindbrain. Previous studies have suggested that competent ectodermal cells respond to signals from adjacent tissues to form the placode. Members of the Fgf family of growth factors and the Dlx family of transcription factors have been implicated in this signal-response pathway. We show that...
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