Article

Spatial Patterning of Otic Vesicles in Human Inner Ear Organoids

2026-07-21

Abstract excerpt

During development axial patterning of the otic vesicle sets up the blueprint for the adult inner ear. While human inner ear organoids recapitulate the initial steps of ear formation, whether and how vesicles are properly regionalised remains unknown. Here, we combine re-analysis of published single-cell transcriptomic datasets with 2D and 3D imaging to assess axial patterning in human stem-cell–derived otic vesic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b006c770-3397-56b6-94c2-8fad89671e1b
DOI: 10.64898/2026.07.20.739576

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial Patterning of Otic Vesicles in Human Inner Ear OrganoidsDOI 10.64898/2026.07.20.739576Read

Morphodynamics of human early brain organoid developmentSemantic proximity Read

Spatiotemporal cellular landscape of the human utricle sensory epitheliumSemantic proximity Read

Deciphering the spatiotemporal transcriptional and chromatin accessibility of human retinal organoid development at the single-cell levelSemantic proximity Read

Deciphering the spatio-temporal transcriptional and chromatin accessibility of human retinal organoid development at the single cell levelSemantic proximity Read

A Single-Cell Level Comparison of Human Inner Ear Organoids and the Human Cochlea and Vestibular OrgansSemantic proximity Read

Defining and Controlling Axial Nephron Patterning in Human Kidney Organoids with Synthetic Wnt-Secreting OrganizersSemantic proximity Read

Multimodal spatiotemporal phenotyping of human organoid developmentSemantic proximity Read

Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial culturesSemantic proximity Read

Decoding morphogen patterning of human neural organoids with a multiplexed single-cell transcriptomic screenSemantic proximity Read

Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory diseaseSemantic proximity Read

Integrated spatiotemporal transcriptomic resolution of embryonic palate osteogenesisSemantic proximity Read

Loss of PAX6 alters the excitatory/inhibitory neuronal ratio in human cerebral organoidsSemantic proximity Read