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Article

Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode.

Development (Cambridge, England) - 1 Jul 2008

Jayasena Chathurani S, Ohyama Takahiro, Segil Neil, Groves Andrew K

Abstract excerpt

The inner ear derives from a patch of ectoderm defined by expression of the transcription factor Pax2. We recently showed that this Pax2(+) ectoderm gives rise not only to the otic placode but also to the surrounding cranial epidermis, and that Wnt signaling mediates this placode-epidermis fate decision. We now present evidence for reciprocal interactions between the Wnt and Notch signaling pathways during inner...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18495817
DOI: 10.1242/dev.017905
PMCID: PMC2575054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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