Article
EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2001
Rosenfeldt H M, Hobson J P, Maceyka M, Olivera A, Nava V E, Milstien S, Spiegel S
Abstract excerpt
Sphingosine-1-phosphate (SPP), formed by sphingosine kinase, is the ligand for EDG-1, a GPCR important for cell migration and vascular maturation. Here we show that cytoskeletal rearrangements, lamellipodia extensions, and cell motility induced by platelet-derived growth factor (PDGF) are abrogated in EDG-1 null fibroblasts. However, EDG-1 appears to be dispensable for mitogenicity and survival effects, even...
Topics
- 3T3 Cells
- Animals
- Apoptosis
- Biological Transport
- Cell Division
- Cell Movement
- Cells, Cultured
- Chemotaxis
- Cytoskeleton
- DNA
- Embryo, Mammalian