Article
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.
The Journal of clinical investigation - 1 Oct 2000
Liu Y, Wada R, Yamashita T, Mi Y, Deng C X, Hobson J P, Rosenfeldt H M, Nava V E, Chae S S, Lee M J, Liu C H, Hla T, Spiegel S, Proia R L
Abstract excerpt
Sphingolipid signaling pathways have been implicated in many critical cellular events. Sphingosine-1-phosphate (SPP), a sphingolipid metabolite found in high concentrations in platelets and blood, stimulates members of the endothelial differentiation gene (Edg) family of G protein-coupled receptors and triggers diverse effects, including cell growth, survival, migration, and morphogenesis. To determine the in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.