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Article

Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity.

Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2009

Quinn Brendan J, Welch Emily J, Kim Anthony C, Lokuta Mary A, Huttenlocher Anna, Khan Anwar A, Kuchay Shafi M, Chishti Athar H

Abstract excerpt

As mediators of innate immunity, neutrophils respond to chemoattractants by adopting a highly polarized morphology. Efficient chemotaxis requires the formation of one prominent pseudopod at the cell front characterized by actin polymerization, while local inhibition suppresses the formation of rear and lateral protrusions. This asymmetric control of signaling pathways is required for directional migration along a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19897731
DOI: 10.1073/pnas.0906761106
PMCID: PMC2785254

Genes

PIP
MPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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