Article
Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury.
Circulation - 27 Nov 2001
Undas A, Brummel K, Musial J, Mann K G, Szczeklik A
Abstract excerpt
BACKGROUND: Mechanisms by which the Pl(A2) (Leu33Pro) polymorphism of beta(3) integrins could lead to an increased risk for coronary events are unclear. This study was designed to examine the effect of this polymorphism on blood coagulation. METHODS AND RESULTS: In normal subjects (12 with Pl(A1A1), 9 with Pl(A1A2), and 3 with Pl(A2A2)), we evaluated the activation of prothrombin, factor V, and factor XIII and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.