Article
Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease.
Thrombosis research - 1 Jan 2007
Dropinski Jerzy, Musial Jacek, Sanak Marek, Wegrzyn Wojciech, Nizankowski Rafal, Szczeklik Andrew
Abstract excerpt
OBJECTIVE: The diallelic glycoprotein IIIa polymorphism P1A1/A2 was attributed to be an inherited risk factor for coronary events. Whether this polymorphism affects response to aspirin in patients with coronary artery disease is not known. METHODS: We assessed thrombin generation (prothrombin fragment F1+2) in consecutive blood samples collected from bleeding-time wounds in 28 men with coronary artery disease;...
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