Article
Molecular mechanisms of prothrombotic risk due to genetic variations in platelet genes: Enhanced outside-in signaling through the Pro33 variant of integrin beta3.
Experimental biology and medicine (Maywood, N.J.) - 1 May 2006
Vijayan K Vinod, Bray Paul F
Abstract excerpt
In recent years inherited variations in platelet proteins have emerged as potential risk factors that could predispose individuals to arterial thrombosis. Although many studies have examined the association of platelet gene polymorphisms with particular disease states, the underlying mechanisms by which most of these polymorphisms contribute to the pathophysiology of thrombosis have remained largely unexplored....
Topics
- Animals
- Blood Platelets
- Humans
- Integrin beta3
- Phenotype
- Platelet Membrane Glycoprotein IIb
- Platelet Membrane Glycoproteins
- Polymorphism, Genetic
- Proline
- Risk Factors
- Signal Transduction
- Thrombosis