Platelet glycoprotein IIIa Leu33Pro gene polymorphism and coronary artery disease: A meta-analysis of cohort studies.

doi:10.3109/09537104.2014.948839

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Article

Platelet glycoprotein IIIa Leu33Pro gene polymorphism and coronary artery disease: A meta-analysis of cohort studies.

Platelets - 1 Jan 2015

Verdoia Monica, Cassetti Ettore, Schaffer Alon, Di Giovine Gabriella, De Luca Giuseppe

Abstract excerpt

Great interest has been focused in the last year on genetic predictors of cardiovascular risk. Glycoprotein IIb/IIIa (GP IIb/IIIa), fibrinogen receptor, is the final common pathway for aggregation and a key point for atherothrombosis. A single nucleotide polymorphism of IIIa subunit (Leu33Pro-PlA(1)/PlA(2) allele) has been suggested to increase aggregation and adhesion, however, contrasting reports have been...

Topics

Aged
Amino Acid Substitution
Cohort Studies
Coronary Artery Disease
Female
Genotype
Humans
Integrin beta3
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide

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PMID: 25167197
DOI: 10.3109/09537104.2014.948839

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