Article
Anti-thrombotic action of clopidogrel and P1(A1/A2) polymorphism of beta3 integrin in patients with coronary artery disease not being treated with aspirin.
Thrombosis and haemostasis - 1 Dec 2005
Dropinski Jerzy, Musial Jacek, Jakiela Bogdan, Wegrzyn Wojciech, Sanak Marek, Szczeklik Andrew
Abstract excerpt
Individual variability in response to clopidogrel is known but its mechanism is poorly understood. We examined the relationship between glycoprotein IIIa polymorphism P1(A1/A2) and anti-thrombotic actions of clopidogrel. Clopidogrel (75 mg/d; 2 weeks) was administered to 48 normolipemic patients with coronary artery disease. Bleeding time, thrombin generation at the site of microvascular injury, platelet function...
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