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Article

Aspirin alters the cardioprotective effects of the factor XIII Val34Leu polymorphism.

Circulation - 7 Jan 2003

Undas Anetta, Sydor Wojciech J, Brummel Kathleen, Musial Jacek, Mann Kenneth G, Szczeklik Andrew

Abstract excerpt

BACKGROUND: The mechanism underlying decreased risk for myocardial infarction in carriers of the Leu34 polymorphism of the factor (F) XIII A-subunit is unclear. Given that acetylation of fibrinogen by aspirin can alter its clotting properties and the presence of fibrin stimulates thrombin-mediated activation of FXIII, we have tested the hypothesis that treatment with aspirin differentially modulates the influence...

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Source

Identifiers

PMID: 12515735
DOI: 10.1161/01.cir.0000047062.03282.a3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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