Article
Platelet glycoprotein IIIa Pl(a) polymorphism, fibrinogen, and platelet aggregability: The Framingham Heart Study.
Circulation - 10 Jul 2001
Feng D, Lindpaintner K, Larson M G, O'Donnell C J, Lipinska I, Sutherland P A, Mittleman M, Muller J E, D'Agostino R B, Levy D, Tofler G H
Abstract excerpt
BACKGROUND: Recent data suggest that the Pl(A2) allele of the platelet glycoprotein IIIa receptor may be a genetic risk factor for cardiovascular disease. We previously reported that the Pl(A2) allele was associated with increased platelet aggregability, as indicated by lower epinephrine threshold concentrations. Paradoxically, however, it has been reported that Pl(A2)-positive platelets have reduced fibrinogen...
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