Article
The GNB3 C825T polymorphism influences platelet aggregation in human whole blood.
Pharmacogenetics and genomics - 1 Jan 2012
Dusse Fabian, Frey Ulrich H, Bilalic Adisa, Dirkmann Daniel, Görlinger Klaus, Siffert Winfried, Peters Jürgen
Abstract excerpt
BACKGROUND: Platelet aggregation varies among individuals; and genetic factors may alter platelet activation through G-protein-coupled receptors, thus influencing results of point-of-care platelet aggregometry in whole blood. We tested the hypothesis that the C825T polymorphism of the gene GNB3 e...
Topics
- 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
- Adolescent
- Adult
- Alleles
- Collagen
- Epinephrine
- Genotype
- Heterotrimeric GTP-Binding Proteins
- Heterozygote
- Humans
- Integrin beta3
- Male
- Middle Aged
- Peptide Fragments
- Platelet Activation
- Platelet Aggregation
- Polymorphism, Single Nucleotide
- Receptors, Purinergic P2Y12