Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of acute somatosensory pain transmission in P/Q-type Ca(2+) channel mutant mice, leaner.

FEBS letters - 16 Nov 2001

Ogasawara M, Kurihara T, Hu Q, Tanabe T

Abstract excerpt

To study the role of the Ca(v)2.1/alpha(1A) (P/Q-type) Ca(2+) channel in somatosensory pain processing, behavioral and electrophysiological studies were conducted using the leaner (tg(la)/tg(la)) mouse. Behavioral analyses in tg(la)/tg(la) revealed reduced responses to mechanical stimuli, and enhanced responses to heat stimuli. Electrophysiological analyses showed that tg(la)/tg(la) had a significantly reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Calcium Channel Blockers
Share to Calcium Channels, N-Type

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Capsaicin

Share to Electrophysiology

Share to Pain Measurement

Share to Receptors, GABA-A

Source

Identifiers

PMID: 11718712
DOI: 10.1016/s0014-5793(01)03052-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of acute somatosensory pain transmission in P/Q-type Ca(2+) channel mutant mice, leaner.PMID 11718712Read ↗

Effects of ablation of N- and R-type Ca(2+) channels on pain transmission.Semantic proximity Read ↗

Disentangling Schwann Cell and Neuronal TRPA1 Function in Mouse Models of Familial Episodic Pain SyndromeSemantic proximity Read ↗

NaV1.8/NaV1.9 double deletion mildly affects acute pain responses in miceSemantic proximity Read ↗

Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.Semantic proximity Read ↗

Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.Semantic proximity Read ↗

Cav3.2 calcium channels involvement in inflammation and related pain-like symptoms in murine inflammatory modelsSemantic proximity Read ↗

Pain genes?: natural variation and transgenic mutants.Semantic proximity Read ↗

Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays.Semantic proximity Read ↗

Targeting <i>Tmem63b</i> and <i>Piezo2</i> in C-fiber low threshold mechanoreceptor: limitation of <i>Vglut3</i> -IRES- <i>Cre</i>Semantic proximity Read ↗

A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain.Semantic proximity Read ↗

Cold hypersensitivity increases with age in mice with sickle cell diseaseSemantic proximity Read ↗

TRP vanilloid 2 knock-out mice are susceptible to perinatal lethality but display normal thermal and mechanical nociception.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.