Article
Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain.
PloS one - 1 Jan 2014
Gingras Jacinthe, Smith Sarah, Matson David J, Johnson Danielle, Nye Kim, Couture Lauren, Feric Elma, Yin Ruoyuan, Moyer Bryan D, Peterson Matthew L, Rottman James B, Beiler Rudolph J, Malmberg Annika B, McDonough Stefan I
Abstract excerpt
Clinical genetic studies have shown that loss of Nav1.7 function leads to the complete loss of acute pain perception. The global deletion is reported lethal in mice, however, and studies of mice with promoter-specific deletions of Nav1.7 have suggested that the role of Nav1.7 in pain transduction depends on the precise form of pain. We developed genetic and animal husbandry strategies that overcame the...
Topics
- Animals
- Disease Models, Animal
- Female
- Humans
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- NAV1.7 Voltage-Gated Sodium Channel