Article
Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.
Proceedings of the National Academy of Sciences of the United States of America - 14 Nov 2006
Field Mark J, Cox Peter J, Stott Emma, Melrose Heather, Offord James, Su Ti-Zhi, Bramwell Steve, Corradini Laura, England Steven, Winks Joanna, Kinloch Ross A, Hendrich Jan, Dolphin Annette C, Webb Tony, Williams Dic
Abstract excerpt
Neuropathic pain is a debilitating condition affecting millions of people around the world and is defined as pain that follows a lesion or dysfunction of the nervous system. This type of pain is difficult to treat, but the novel compounds pregabalin (Lyrica) and gabapentin (Neurontin) have proven clinical efficacy. Unlike traditional analgesics such as nonsteroidal antiinflammatory drugs or narcotics, these...
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