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Article

NaV1.8/NaV1.9 double deletion mildly affects acute pain responses in mice

4 Oct 2024

Abstract excerpt

ABSTRACT: The 2 tetrodotoxin-resistant (TTXr) voltage-gated sodium channel subtypes Na V 1.8 and Na V 1.9 are important for peripheral pain signaling. As determinants of sensory neuron excitability, they are essential for the initial transduction of sensory stimuli, the electrogenesis of the action potential, and the release of neurotransmitters from sensory neuron terminals. Na V 1.8 and Na V 1.9, which are...

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PMID: 39382328
DOI: 10.1097/j.pain.0000000000003411

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