Article

Targeting <i>Tmem63b</i> and <i>Piezo2</i> in C-fiber low threshold mechanoreceptor: limitation of <i>Vglut3</i> -IRES- <i>Cre</i>

2025-07-31

Abstract excerpt

Peripheral somatosensory neurons in the dorsal root ganglia (DRG) transduce mechanical force in the skin and other organs into electrical signals using specialized mechanically activated (MA) ion channels that initiate neuronal activation in response to force. Increasing evidence highlights PIEZO2 as the primary transducer of low-threshold mechanical force in DRG neurons. However, in the absence of Piezo2 , mice...

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Literature Corpus work: 2a0ede17-da79-5a41-a119-0032fc7a3132
DOI: 10.1101/2025.07.26.666969

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