Article
A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain.
Proceedings of the National Academy of Sciences of the United States of America - 5 Apr 2011
Lagerström Malin C, Rogoz Katarzyna, Abrahamsen Bjarke, Lind Anne-Li, Olund Caroline, Smith Casey, Mendez José Alfredo, Wallén-Mackenzie Åsa, Wood John N, Kullander Klas
Abstract excerpt
Ablating or functionally compromising sets of sensory neurons has provided important insights into peripheral modality-specific wiring in the somatosensory system. Inflammatory hyperalgesia, cold pain, and noxious mechanosensation have all been shown to depend upon Na(v)1.8-positive sensory neurons. The release of fast-acting neurotransmitters, such as glutamate, and more slowly released neuropeptides, such as...
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